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KMID : 0359920080270030307
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Korean Journal of Nephrology
2008 Volume.27 No. 3 p.307 ~ p.318
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15-Deoxy-Delta(12,14)-Prostaglandin J2 and Proinflammatory Cytokines in IgA Nephropathy
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Jeong You-Seok
Song Sang-Heon
Lee Dong-Won
Lee Soo-Bong
Yang Byeong-Yun
Kwak Ihm-Soo
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Abstract
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Purpose: This study was performed to demonstrate a correlation among urinary 15d-PGJ2, proinflammatory cytokines (i.e. IL-23, IL-6, and TGF-β1), and CRP, and to determinate the contributors to prognostic score and proteinuria in IgAN patients.
Methods: Fifty-four patients with biopsy-proven IgAN were enrolled. For comparison with IgAN, five MCD patients were also enrolled. Immunohistochemical staining for PPAR-γ in kidney tissue and measurements of urinary IL-6, IL-23, TGF-β1, 15d-PGJ2 and serum CRP were performed
Results: There was no difference according to PPAR-γ staining. 15d-PGJ2 was negatively correlated with urinary IL-23, TGF-β1, and CRP. Among proinflammatory cytokines and CRP, there were positive relationships with each other except for IL-23 and CRP. TGF-β1 in the group having proteinuria more than 3 g/day was statistically higher than that in the sole hematuria group. However, in multivariate regression analysis, not a single relation was found between TGF-β1 and proteinuria. Prognostic score was correlated with IL-6, IL-23, TGF-β1, CRP, 15d-PGJ2, and 24hr proteinuria. 24hr proteinuria was correlated with IL-6 and 15d-PGJ2. In multivariate regression analysis, CRP, 15d-PGJ2, and 24hr proteinuria contributed to prognostic score, and only 15d-PGJ2 contributed to 24hr proteinuria. Last, urinary 15d-PGJ2 in IgAN was higher than that in MCD.
Conclusion: Endogenous 15d-PGJ2 was associated with inflammation and might be considered as a material which could delay the damage of kidney in IgAN. In the future, larger cohort and long-term follow-up studies are needed to demonstrate the role of 15d-PGJ2 as prognostic indicator or marker of kidney damage.
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KEYWORD
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Immunoglobulin A nephropathy, 15-deoxy-delta (12, 14)-prostaglandin J2, Peroxisome proliferator-activ
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